2-Pyridinamine, 5-[4,6-bis(3-oxa-8-azabicyclo[3.2.1]oct-8-yl)-1,3,5-triazin-2-yl]-4-(difluoromethyl)-
PQR620
CAS: 1927857-56-4
Molecular Formula: C21H25F2N7O2
2-Pyridinamine, 5-[4,6-bis(3-oxa-8-azabicyclo[3.2.1]oct-8-yl)-1,3,5-triazin-2-yl]-4-(difluoromethyl)- - Names and Identifiers
| Name | PQR620 |
| Synonyms | PQR620 PQR-620 PQR 620 2-Pyridinamine, 5-[4,6-bis(3-oxa-8-azabicyclo[3.2.1]oct-8-yl)-1,3,5-triazin-2-yl]-4-(difluoromethyl)- |
| CAS | 1927857-56-4 |
2-Pyridinamine, 5-[4,6-bis(3-oxa-8-azabicyclo[3.2.1]oct-8-yl)-1,3,5-triazin-2-yl]-4-(difluoromethyl)- - Physico-chemical Properties
| Molecular Formula | C21H25F2N7O2 |
| Molar Mass | 445.47 |
| Density | 1.403±0.06 g/cm3(Predicted) |
| Boling Point | 706.8±70.0 °C(Predicted) |
| pKa | 5.12±0.10(Predicted) |
| Storage Condition | -20℃ |
2-Pyridinamine, 5-[4,6-bis(3-oxa-8-azabicyclo[3.2.1]oct-8-yl)-1,3,5-triazin-2-yl]-4-(difluoromethyl)- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.245 ml | 11.224 ml | 22.448 ml |
| 5 mM | 0.449 ml | 2.245 ml | 4.49 ml |
| 10 mM | 0.224 ml | 1.122 ml | 2.245 ml |
| 5 mM | 0.045 ml | 0.224 ml | 0.449 ml |
Last Update：2024-01-02 23:10:35
2-Pyridinamine, 5-[4,6-bis(3-oxa-8-azabicyclo[3.2.1]oct-8-yl)-1,3,5-triazin-2-yl]-4-(difluoromethyl)- - Reference Information
| biological activity | PQR620 is a novel, selective, orally bioavailable, dual Inhibitors of TORC1/2 with brain permeability. PQR620 had antitumor activity in the 56 lymphoma model assay, with a mean IC50 value of 250 nM at 72 hours of treatment. |
| Target | Value |
| TORC1 (Cell-based assay) | 250 nM |
| TORC2 (Cell-free assay) | 250 nM |
Last Update：2024-04-09 21:04:16
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Spot supply
Product Name: PQR620 Visit Supplier Webpage Request for quotationCAS: 1927857-56-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History
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